Tag: 南京水韵温泉85刺激

Search on for missing Limerick teen

first_imgGardai wish to seek the public’s assistance in tracing the whereabouts of 16 year old Darnell Price who is missing from Limerick.Darnell was last seen on the afternoon of January 26 on O’Connell Street, Limerick. He is described as being 5′ 6″ tall, of slight build and with brown hair. When last seen he was wearing a green Jacket, navy blue track suit and blue runners.Sign up for the weekly Limerick Post newsletter Sign Up Anyone who has seen Darnell or who can assist in locating him is asked to contact Henry Street Garda Station on 061-212400, The Garda Confidential Telephone Line 1800 666 111 or any Garda Station. Linkedin Advertisement Previous articleMaking Capital on centuries of AdventureNext article€12.5 million to be spent on Limerick city Staff Reporterhttp://www.limerickpost.ie Email TAGSfeatured NewsBreaking newsSearch on for missing Limerick teenBy Staff Reporter – January 30, 2016 779 Proceedures and appointments cancelled again at UHL Surgeries and clinic cancellations extended WhatsAppcenter_img Shannondoc operating but only by appointment Walk in Covid testing available in Limerick from Saturday 10th April Twitter First Irish death from Coronavirus RELATED ARTICLESMORE FROM AUTHOR Print Facebook No vaccines in Limerick yet last_img read more

Engineered mini-kidneys come of age

first_img The first fully 3-D-printed heart-on-a-chip A glomerulus-on-a-chip could model patient-specific kidney diseases, guide therapeutic discovery Human stem cells model the kidney’s filtration barrier With organs-in-a-dish a growing success story, research with organoids has increasingly proved its worth. Already, scientists can create organoids that have many of the cell types and complex architectures of human organs such as the kidney, liver, guts, and even the brain.Most organoids grown in vitro , however, have lacked the vasculature to provide the cells with oxygen and nutrients, remove metabolic waste, and facilitate communication between cell types — functions that drive their maturation into working tissue-building blocks.When it comes to kidney organoids, that shortcoming has kept researchers from reproducing key functions, such as blood filtration, reabsorption, and urine production. A vascularized organoid could better model kidney diseases, enhance renal drug toxicity testing, and ultimately lead to building blocks for replacement therapies.To answer that need, a team of researchers from the Wyss Institute for Biologically Inspired Engineering, the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), Brigham and Women’s Hospital, and the Harvard Stem Cell Institute has developed a powerful new approach as part of the Wyss’ new 3D Organ Engineering initiative. By exposing stem cell-derived organoids to fluidic shear stress, they have significantly expanded their vascular networks and improved the maturation of kidney compartments. The work is published in Nature Methods.,The improvements are a next step on a path begun in 2015, when Ryuji Morizane and Joseph Bonventre developed a way to make kidney organoids from human pluripotent stem cells. But while their organoids had well-organized nephrons, which filter the blood, and primitive blood vessels,  “they still lacked pervasive vascular compartments with perfusable lumens,” said Morizane, an assistant professor at Brigham and Women’s Hospital and Harvard Medical School (HMS), a member of the Harvard Stem Cell Institute, and, with co-author Jennifer Lewis, co-leader of the research team.To develop these, the team used the Lewis lab’s strategies to create vascularized human tissues, including 3-D kidney-on-chip models, using perfusable and durable 3-D bioprinting. They hypothesized that fluid flow could help the chip models form blood vessels from precursor endothelial cells found in growing kidney organoids — and successfully, for the first time, demonstrated that by exposing the organoids to fluid flow, their vascularization and maturation can be enhanced in vitro, rather than in an animal host, said Morizane.A developing glomerulus in a kidney organoid cultured under flow showing invasion by a single capillary, which is an important step in nephron development. Credit: Wyss Institute at Harvard University“We determined the right combination of underlying extracellular matrix, media additives, and fluidic shear stress under which human stem-cell derived organoids would flourish when grown in our 3-D-printed millifluidic chips,” said Kimberly Homan, a research associate in Lewis’ group and, with Navin Gupta, first author on the study.“The vascular networks form close to the epithelial structures that build the glomerular and tubular compartments, and in turn promote epithelial maturation. This integrated process works really like a two-way street,” said Gupta, a clinical research fellow in Morizane’s lab.“This important advance opens up new avenues for accurately testing drug toxicity in vitro … and modeling kidney diseases, like polycystic kidney disease, that affect specific structures and cell types using patient-derived stem cells as the starting point,” said Lewis, who is a core faculty member of the Wyss Institute and co-leader of its 3D Organ Engineering Initiative. Lewis is also the Hansjörg Wyss Professor of Biologically Inspired Engineering at SEAS and a member of the Harvard Stem Cell Institute.“Our method may pave the way to also vascularize other types of organoids, such as the liver organoids,” she said.“This study is a great example of the importance of mechanobiology and the potential power of the Wyss Institute’s 3D Organ Engineering Initiative. It provides an important cornerstone for many efforts that aim to create functional human tissues de novo for research, pharmaceutical, and tissue regenerative applications,” said Wyss Institute Founding Director Donald Ingber, who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children’s Hospital, as well as professor of bioengineering at SEAS.Other authors on the study are Bonventre, the Samel A. Levine Professor of Medicine at HMS, chief of renal medicine at the Brigham, and a member of the Harvard Stem Cell Institute; past and present members of Lewis’ team, including Katharina Kroll, Mark Skylar-Scott, David Kolesky, Donald Mau, and Thomas Ferrante; Tomoya Miyoshi on Morizane’s team; and M. Todd Valerius, principle investigator at the Brigham.The study was funded by the National Institutes of Health, Harvard’s Wyss Institute for Biologically Inspired Engineering, and the Harvard Stem Cell Institute. Wyss Institute’s goal is to improve America’s ability to respond to nuclear radiation incidentscenter_img Related Organs-on-chips evaluate therapies for lethal radiation exposure Technique paves the way for more complex, customizable devices last_img read more

Real Madrid beat Atlético in shootout, claim Spanish Super Cup

first_img Captain Sergio Ramos converted the decisive fourth penalty for Real after Dani Carvajal, Rodrygo Goes and Luka Modric had scored for his side while Saul Niguez and Thomas Partey failed to convert for Atletico, with Kieran Trippier scoring for them. Promoted ContentA Hurricane Can Be As Powerful As 10 Atomic Bombs8 Things You Didn’t Know About CoffeeHere Are The Top 10 Tiniest Mobile Phones On The Planet!8 Superfoods For Growing Hair Back And Stimulating Its GrowthThe Highest Paid Football Players In The World10 Extremely Gorgeous Asian ActressesPortuguese Street Artist Creates Hyper-Realistic 3D Graffiti7 Universities In The World With The Highest Market Value7 Mind-Boggling Facts About Black HolesWhich Country Is The Most Romantic In The World?7 Universities In The World Where Education Costs Too MuchThe Very Last Bitcoin Will Be Mined Around 2140. Read More Atletico keeper Jan Oblak and Real counterpart Thibaut Courtois were the top performers in a cagey 90 minutes which forced extra time for the fifth consecutive final between the city rivals since 2013.Advertisement Loading… Real had midfielder Federico Valverde sent off in the 115th minute for hauling down Alvaro Morata but Zinedine Zidane’s side survived the final stretch of the game and kept their nerve in the shoot-out. Real Madrid beat city rivals Atletico Madrid 4-1 in a penalty shoot-out to win the first edition of the revamped Spanish Super Cup in Saudi Arabia following a goalless draw after extra time in a tense final on Sunday night. Real Madrid: Liverpool plot £90m transfer move for Barcelona winger It is the 11th time Real have won the Super Cup, which was the traditional season curtain-raiser between the league and Cup winners before the competition was expanded to four teams by the national federation and moved to Saudi Arabia in a three-year deal worth a reported 120 million euros. FacebookTwitterWhatsAppEmail分享 last_img read more

Appiah: Sudan game is the most important

first_imgGhana coach has urged his Black Stars not to look at the table rather concentrate on their FIFA World Cup qualifying match against Sudan.The Black Stars head into the match in Kumasi sitting second and three points behind Zambia in the group and know nothing less than three points are likely keep them in the hunt of reaching the top.Kwesi Appiah says there is still a long road to go in the second round qualifying campaign, which reaches the halfway stage this weekend.“Our first two games mean nothing now. The most important game for us is the game against Sudan and that is what we are focusing on now,” Appiah said.“It is a long road to reaching the finals in Brazil. And we must beat them [Sudan] to stay on track. The table is a reflection of results so far but our campaign has always been in our hands.“We must focus on beating Sudan and see where that takes us.” After consecutive appearances at the finals in 2006 and 2010, the hopes of a third depends on what the present generation of Black Stars achieve in the qualifiers.For Appiah, the Black Stars can draw inspiration from two previous World Cup appearances in their bid to secure qualification for the 2014 finals in Brazil.“The World Cup is a great sporting event that every player dreams of. A few members of the present team have had that opportunity but I believe the rest can draw motivation from that.“They should have that desire of wanting to be in Brazil and make sure that they carry that dream through.“We need to go out there and take the points and keep on like that,” the Ghana coach said.last_img read more